Your condition may be a result of a collective number of other genetic and environmental factors. Keep in mind that if you are suffering from undermethylation, you may not experience every symptom on this list. In the morning I feel tired and there is lack of motivation and in the evening I feel more energy. Pumpkin Elevated whole blood histamine suggests undermethylation, whereas low whole blood histamine suggests overmethylation, but other factors and symptoms should always be taken into account. Why is it a problem? Good luck! I recently bought niacin, folic acid and b12 and I felt relief 10 minutes after I took my dose. If you are dealing with overmethylation, many experts will recommend a specific supplement regimen over the course of 3 to 6 months. The removal of methyl groups is called demethylation. These are figuratively countless numbers of on/off switches that regulate countless processes in your body including the immune system, DNA maintenance, hormone production . document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); 2022 Dr. Jill Health, Inc. | 400 S. McCaslin Blvd, Suite 210, Louisville, Colorado 80027 | Site by Yakadanda. Undermethylation reduces the production of serotonin and dopamine. The purpose of this site is to bring together the scientific and the anecdotal, the personal and the professional, the supporters and the haters in light of helping you to understand Undermethylation. Yang X, Feng L, Zhao L, Liu X, Hassani D, Huang D. J Sci Food Agric. Ive never felt like they have helped with much, except for Glucosamine and Chondroitin for joint pain. Commercial dairy is basically a garbage food it is pasteurised (high temperature heated) which denatures proteins and destroys enzymes required to digest lactose. I recommend the book Dirty Genes. After 144 h, over 50% of applied caffeine dissipated in the hydroponic lettuce system, and eight caffeine metabolites were identified primarily in the shoots. This may be related to elevated levels of histamine, leading to more pronounced reactions. undermethylation and caffeine. Consider Acetylcholine. The MTHFR factor being diagnosed was significant as a turning point in my health. Do you think that SAMe would help? Working with a professional will help you come up with a supplement regimen that effectively offsets the overmethylation. Niacinamide may really help the anxiety and other mental issues Id start low, maybe 50-100mg and ramp it up it wont cause the flushing. Raw Sheep Cheese MeSH Eggplant I have had 23AndMe analysis. In many cases, high serotonin levels can cause psychological problems including reduced motivation, reduced libido,weight gain, and confusion. For example, should I take Sam-e? I try to limit dairy, but otherwise no other food sensitivities. Assuming you are suffering from undermethylation, there are numerous supplements you can consider for treatment. Your personal data will be used to support your experience throughout this website, to manage access to your account, and for other purposes described in our privacy policy. My doctor put me onto a vitamin B and folate mix and I have also been to a naturopath. Dr. Mensah (Mensah medical website), does a really good job of breaking down this topic and how to get tested. Perfectionism, High achievement: Essentially Undermethylatorshave low levels of SAM-e, which donates methyl. Keep up the great work. Epub 2020 Apr 6. Is this enough to help me with my overmethylation problem or do I need to supplement with more stuff? I have participated in a similar study with a cohort of 1. Coconut Milk He said histamine, not Hcy. I was diagnosed with Scoliosis, Fibromyalgia, Sjogrens, AMD, heterozygous for MTHFR and have had severe anxiety all my life. There isnt anything wrong with being overmethylated nor undermethylated, but it may cause some sort of mental distress. This enzyme shows an optimum pH of about 6.0, and the optimum temperature is in the range of 22-24 degrees C. The enzyme is absolutely depende So in my case I have MTHFR C77T +/-.would this lead to overmethylation? Ingesting high levels of folic acid can be toxic for those with MTHFR gene mutation. This in turn can result in low levels of neurotransmitters such as serotonin and dopamine thehappy chemicals. The following is a list of characteristics and factors associated with undermethylation. Hi Jen. 2013. Watercress, Anchovies It might be the body's way of dealing with excess histamine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. When the gene is considered abnormal, the methyl cycle may function abnormally. Lots of research done on niacinamide for mental problems up to and including schizophrenia Google it. Is your digestive system functioning better? Vitamin B6 < I am an undermethylator and high copper. Important nutrients to support undermethylators include getting more methyl donors in the diet: *Methionine and Sam-e act as natural selective serotonin reuptake inhibitors (SSRIs) that can aid in increasing serotonin or the 'feel good hormone' in the brain. Before Required fields are marked *. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); This site uses Akismet to reduce spam. I am willing to partake in studies, tests or any trials that may be going but nowhere seems to be taking anyone on at this time. Your email address will not be published. Would you like email updates of new search results? Bell Peppers Zinc, This is the best article I have read and the most accurate. Gluten sensitivity (not necessarily just celiac) can have amazingly severe mental symptoms! Both extremes can cause unpleasant and uncomfortable symptoms, many impacting mental health. Understand that overmethylation will not necessarily cause every single symptom on the list and that severity of each symptom is highly subject to individual variation. The site is secure. Histamine is also found in food, so a high histamine diet can impact blood histamine levels. Also women who are pregnant, trying to become pregnant or breastfeeding are advised to limit their use of caffeine. He is clear that the ratio between methyl groups and folate is critical to consider brilliant guy if you ask me! Fennel I believe I am an overmethylator waiting for the Whole Blood Histamine test results. Mixing caffeine with this medication which is used in decongestants might increase your risk of high blood pressure, heart attack, stroke or seizure. Coriander Seeds Dr. Jill is a functional medicine expert consultant and treats environmental and mold-related illness as well. If you know for a fact that undermethylation is the problem, taking a targeted nutritional approach is your best bet. Grouper Avocado Oil Pharmaceuticals can be metabolized after being taken up by plants. He is so nervous about trying any additional supplements at this point. Thanks, Steve. So let's briefly revisit methylation. Duck Methylation is profoundly connected to mental health. Broccoli 2019 Apr;247:1134-1142. doi: 10.1016/j.envpol.2019.02.009. He flushes dramatically with only 50mg of Niacin (as nicotinic acid). I agree with Vanessa my family has had good benefit from using Mensah Medical. Hempseed Oil He just wants to give up. Undermethylators are often involved in activity that naturally raises dopamine levels. There are 3 duplications that can be used for either methylators. What You Can Do. I guess Im just throwing this out there in case it helps someone suffering similarly. I have A1298C heterogeneous and will be going to see a functional medicine doctor later this month. I am based in the UK and would like to get tested for Methylation and other renamed tests, but dont know where to start. Those who undermethylate also tend to have low levels of neurotransmitters, which may increase their risk of depression, anxiety, and . So, there are inaccuracies in this article but overall it is helpful. Hope some of these help. Required fields are marked *. If you are at risk of anaphylactic for any reason I would definitely have an epi pen around. Generally treatment doesnt yield drastic improvement overnight, and in some cases it can take 8 to 12 months before a person feels noticeably better. Proteins high in cysteine, glycine and glutamate will help to top up your glutathione levels. Get hold of Dr Natasha Campbell-McBrides book Gut and Pyschology Syndrome. In my opinion, everyone has to experiment for itself. Strawberries According to this website low homocysteine is an indicator of undermethylation. For the first 8 hours after taking even that much, his anxiety and agitation is very intensified, but then he has a period where he feels goodvery calm and ok for the next 6 hours. I used almost all types of antidepressants for years without any benefit. This can lead to low levels of serotonin, making them susceptible to depression. Anyway just thought Id offer myself as a glimpse into the mind of an overmethylator haha, hope she finds healing soon. So we make no warranties, either express or implied, to the suitability of any piece of information or product for a specific purpose. MentalHealthDaily.com 2013-2019 | Privacy Policy | Legal Notice | Affiliate Disclosure, Magnesium Deficiency Symptoms, Causes, & Treatments, Seasonal Affective Disorder (SAD): Causes, Symptoms, Treatment, Sleep Paralysis: Causes, Symptoms, & Treatment, Catatonic Depression: Symptoms, Causes, & Treatment Options, Intermittent Explosive Disorder (IED): Causes, Symptoms, Treatment, http://www.walshinstitute.org/clinical-resources.html, Fish Oil Side Effects & Adverse Reactions. My thoughts on these products are my own. Is Undermethylation Keeping You Down? What is the reason? Caffeine is a naturally occurring central nervous system (CNS) stimulant of the methylxanthine class and is the most widely taken psychoactive stimulant globally. Additionally you may discover high levels of copper, but low presence of zinc and histamine throughout the body. My Fibromyalgia is gone after stopping Folic Acid and taking natural Folate: along with Magnesium. He has very low homocysteine (5.7), and good B12 levels (about 800). Im not sure why Im commenting. Vegetable oils and other polyunsaturated oils are heavily processed and often rancid by the time they reach the supermarket and are not required for human health. Caffeine decreases my energy and increases my brain fog 90% of the time (I keep trying to repeat this study in case the results come out differently.) I shall not be liable or responsible for any loss or damage allegedly arising from any information or suggestions within this website. My biggest symptom for overmethylation is an extreme insomnia (~90 minutes of sleep per night) and the opposite when undermethylated (~9-12 hours sleep). He has been to every doctor (GP, neurologist, endocrinologist, immunologist, psychiatrist, nutritionist, wellness coach, etc). I learned about leaky gut/brain and realized this could be why all these supplements have no helped. Blueberries Sorry to hear of that kind of a response to a caffeine tablet. Some of these symptoms for conditions such as depression and schizoaffective disorder (among others) include: Delusions Perfectionism Seasonal Allergies High accomplishment Suicidal Addictions Phobias Peptic Ulcers Denial of Illness Most sources just assume high homocysteine with undermethylation and recommend methylfolate, as did his integrative doctor. apartments under $800 in delaware / innsbrook golf course dress code / undermethylation and caffeine. Pineapple Posted by ; gatsby lies about his wealth quote; north korea central bank rothschild . The presence of 30-50% of the factors may be sufficient for diagnosis. There are numerous other SNPs that could influence methylation status, not nust this one. Fish Oil Causing Depression or Anxiety? Continuing Education Activity. Walnut Oil, Goat Cheese Folate is the one you can take. 2017 Jun 7;65(22):4526-4535. doi: 10.1021/acs.jafc.7b01667. USA Distributor of MCM Equipment undermethylation and caffeine Please help me. Things that increase cortisol production generally are positive for me. You seem to be very knowledgable and I would love to hear more from you on this topic. Functional testing (blood and urine) gives you a picture of what is actually happening in the body, not just a theory of what might be happening. Take care. (I eat a salad every day). You, as a reader of this website, are totally and completely responsible for your own health and healthcare. Eat more dark, leafy greens - You want to eat l cup a day of vegetables like bok choy, escarole, Swiss chard, kale, watercress, spinach, or dandelion, mustard, collard, or beet greens. Anne, So sorry to hear this. That is the best way to find all methylation mutation. FWIW, I am about to have that testing done this week. Kale Jerusalem Artichoke Despite his blood tests showing low homocysteine, she put him on methylfolate which apparently reduces homocysteine because that is what you do for undermethylators. If you are serious about learning whether you truly have a methylation problem, get the MTHFR gene tested and have the results analyzed. Also would be a good idea to have some benedryl around too if you don't think it's going to be a severe reaction. It is also possible to have high copper and be undermethylating if your zinc levels are low already than other metals like copper and lead can be high. They do the methylation test and some vitamin deficiency testing. She may use diet, supplements, lifestyle changes or medication to treat your illness but will seek the most gentle way to help your body restore balance along with the least invasive treatment possible. (Some of them do telephone consultations.). On the other hand, undermethylation can also be associated with high inner tension, depression and obsessive-compulsive tendencies. There are also other testing panels available that look at the SAMe/SAH ratio. Certain opportunistic gut bacteria are histamine-producers and when overgrown increase histamine levels in the body. Dr. Walsh says 23andme is not helpful to determine methylation status. Grains / Gluten (bread, pasta, cookies, pastries, crisp breads, many condiments, many processed foods and ready-made meals, oats, muesli-bars) which can irritate your gut, enter the bloodstream via a leaky gut and cause inflammatory processes. Strong willed: Another characteristic that is found among those who are undermethylated is that of a strong will. This error message is only visible to WordPress admins. It is not intended to be diagnostic in nature and should not be a substitute for individual medical advice, diagnosis or treatment by a health-care practitioner. It's going to be really important for you to go on a whole food plant-based diet. government site. Green Beans Disclaimer. This was a great article, but the recommendations to get the MTHFR test as a sole measure or indicator of methylation status is problematic. This is exactly my son. I have disabling OCD/tics; CBT does not work and medication caused tinnitus and hyperacusis so am unable to return to that route. Hazelnuts What kind of testing should a functional medicine practitioner be doing to evaluate methylation status? The content of our Invitation to Health website is intended to be used as a thought provoking resource as you engage on your journey towards optimal health and wellbeing. I dont think anyone really knows the answer. -High heavy metals If you're bothered by headaches, restlessness or anxiety, you may want to reevaluate your caffeine intake. Avoid Taking Things With Folic Acid. Tomatoes Citrus foods are histamine liberators which increase histamine release and so should also be avoided. [1] It's a vital metabolic process that takes place in every cell and organ in your body. Folic acid depletes methyl groups in the nucleus of the cell where DNA is made. Of course, one can also be a 'normal' methylator with average histamine levels (more on histamine later). I have also low histamine, low basophils, high copper, low zinc. Im also taking lots of supplements, and my son is too. Testing for whole blood histamine is the primary tool for helping to identify methylation status. Your less common overmethylation may be due to a number of other factors, including other genetic mutations, nutritional imbalances, chronic or acute trauma or stress, metal toxicities, radiation exposure, various medications particularly antihistamines and antidepressants, which both lower histamine and increase methylation, food allergies or sensitivities, and food and other environmental chemical exposures. Arugula Avocados When blood contains high levels of histamine, the excess histamine is stored in the blood basophils (a type of white blood cell) and brain neurons. Is this too much? Most people it seems do better for a day or two, week or two and then something swings the other way. Artichoke Here are some of those precursors and cofactors you should add to your diet to help with your undermethylation: Choline - An important methyl donor. Hi there! Because when you know better, you can feel better! If you're a current client of mine, feel free to inquire about mood packages or grab the Mood eCourse on presale (before the price goes up) so you can make sure your body has all the raw materials it needs to support its natural desire for health. Unable to load your collection due to an error, Unable to load your delegates due to an error. HHS Vulnerability Disclosure, Help Avoid all processed foods in packages and tins. -B12 worked initially but now it makes me more sleepy. Theophylline. Rosemary Mackerel It has a calming effect and when undermethylation causes levels to drop, it can result in anxiety or depression. Soy is not a health food. Of course, one can also be a 'normal' methylator with average histamine levels (more on histamine later). Lima Beans (soaked) -High Basophil count Thanks for sharing and I always get so much out of your webinars. Where can you get tested for the MTHFR gene and have it analyzed? Apparently too many citrus fruits can lead to high folate issues in undermethylators so consume moderately. It was such a small amount we could barely see it at the bottom of the capsule (about 15mg). All matters regarding your health require medical supervision. Histamine gets a bad name but in reality we need histamine to help get important immune system elements to injuries and to attack Invaders. I have started vitamins today - zinc, vit c, active b6, magnesium, calcium. That being said, it's a good way to know which way your body might tend to behave. I am an overmethylator. Good information! Vegetables Vegetables provide loads of vitamins, minerals, trace elements and anti-oxidants. Over the course of a year, they nearly eliminated his palpitations, anxiety and obsessions. Though undermethylation and overmethylation both share anxiety as a symptom, people who are experiencing a lack of methylation are typically experiencing anxiety that's more geared towards perfectionism tendencies. I had testing recommended by Dr Walsh and did well on his recommended supplements, with no folate. 1. Omega-3 fatty acids < Please can you clarify, does having an MTHFR genetic mutation make you overmethylated? Seabass I added TMG to my mix to lower homocysteine but wonder how it will affect my higher copper. For patients suffering from yeast overgrowth, temporarily eliminating fruit, honey, and nuts may be beneficial. They are extremely detrimental to digestive system and the healing process. I dont know if I am an under or over methylator. Vivian. How do I determine my MTHFR status? Copper - Many methylation enzymes require copper for reactions. It does not give you a treatment plan, however. They may be intolerant to less-than-perfect outcomes. Sparkling Water While you probably wont notice major benefit overnight, you may start to feel gradually better over the course of several months. An official website of the United States government. I have a SAM/SAH ratio of 4.3 and high levels of SAH but my Doctor and I arent clear if this means overmethylation? The contradictory information is very confusing. Also check out the book Nutrient Power by William J Walsh PhD. Papaya Methylation is the addition of a single carbon and three hydrogen atoms (called a methyl group) to another molecule. homestead high school staff. my headache went away, my eyes relaxed. Penny is a passionate doctor who loves walking in nature. There are numerous factors involved in the methylation cycle which can lead to imbalance not just the MTHFR gene. Obsessive compulsive: Undermethylation may provoke symptoms of OCD or other obsessive tendencies. . Natural folates, for example, found in leafy greens like spinach, kale and broccoli can sometimes help maintain the methylation cycle. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. Hi Kim, I too have the same diagnosis as your sons. With 23AndMe, you can buy the Strategene app (about $40). Metformin. Undermethylation is a mental health condition. Check The Hidden Dangers of Soy by Dianne Gregg and The Whole Soy Story by Dr Kaayla Daniel. Overmethylation is the polar opposite of undermethylation. Histamine rich foods: Foods that are associated with high histamine levels include fermented foods such as sauerkraut, kombucha, pickles, wine, yogurt, mature cheeses and fermented soy products. Excellent suggestions. Although it occurs in all the cells of the body, 85% of methylation takes place in the liver. The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with a medical doctor. I found this article while trying to find info on undermethylators with Low homocysteine (and high blood folate), which is the category by son falls into. 2018 Jan;98(2):467-477. doi: 10.1002/jsfa.8482. Now why would this be problematic? Sheep Yogurt You cant be low in both. You will find research of the above levels indicating overmethylation documented all over Google Scholar, if you wanted to look up to show your doc. Vitamin E Thank you!!! But one thing Ive found thats really helpful with my sons anxiety and paranoia is CBD oil (cannabidiol). Nicholas. Other metabolism pathways included oxidation and hydroxylation, and the amount of metabolites increased over uptake time. Gotta agree with the other replies here genetic testing alone is known for being mis-leading, as you might have SNPs that cancel each other out. If you're interested learning more about overmethylation, I encourage you to check out my blog: Is Overmethylation The Cause of Your Anxiety? You can push yourself into undermethylation with some of these, especially the niacin. It came back positive for c677t. I have other issues, immune related: chronic fatigue, psoriasis and the arthritis, asthma, allergies, believe I have fibromyalgia and M.E. Fermented foods are a focal point in the protocol. How To Reduce It For Better Health, SAMe, methionine, or TMG can also be taken. The goal is to gradually reduce the amount of methylation that occurs with targeted nutritional interventions. Reduction in starches, elimination of processed food. Those who are considered under-methylated have trouble using methyl donors, therefore they may produce the same amount of methyl yet fail to ultilise them optimally. There is nothing good about being an overmethylator. Avoid eating foods which are damaging to the gut, have higher levels of anti-nutrients,are potentiallydamaging or excitatory to the immune system, and to choose foods that are nutritious. Vitamin C <, Overmethylation Many patients have difficult digesting fats in the beginning of the diet and may only be able to tolerate a few tablespoons while the body is healing. Some researchers believe that if a person is a poor methylator, they are likely to have high levels of histamine, reduced zinc, and a high basophil count. They are highly motivated, competitive, perfectionist, high achieving and frequently have successful careers. -Chromium Picolinate (reduces headache 80%) With a forum dedicated to sharing the world's opinions on the topic, the ultimate outcome is an accurate representation of what is Undermethylation. Best of luck! Trout It is true not one thing works for EVERYONE. This will tell you which of your SNPs may affect your methylation. It seems no one has definite answers. Affiliate Link Disclosure: This post contains affiliate links. and EAT THOSE INSTEAD. High libido: highly interested in sex and/or have a higher than average drive compared to others. In an oversimplification, undermethylators have a shortage of methyl groups and can benefit from getting more methyl donors, whereas overmethylators have too many methyl groups. Would anyone know where we can get this test done? I can report the results of a recent study on caffeine use in PWMEs. Refer to the GAPS diet book for further information! If that option is not for you, start paying attention to how your body, mind and emotions respond to the foods / drinks you put in your mouth. Pine Nuts Overmethylation (Histapenia): Too much methyl (a carbon group with three hydrogen atoms). Hcy can blur the interpretation of over or under methylation and is not definite indicator, while everyone almost invariably agrees that elevated all blood Histamine level is the indication of under methylation. Nectarine A basic outline of the GAPS diet includes the following: The GAPS diet should consist of fresh and wild meats (hormone-free/grass fed if possible), healthy fats (animal fats, coconut oil, ghee, cultured butter, organic EV olive oil), wild fish, shellfish, organic farm-fresheggs (if well tolerated), fermented, probiotic-rich foods, and non-starchy vegetables. Never in the history of humanity has soy been consumed in the manner it is today. Most naturopaths can organize this test for you in NZ. Please note, some patients are unable to tolerate these products in the beginning and may need to be temporarily avoided. There is also a tendency for higher histamine. It's probably the combination of different SNPs that amount to a response, since there is so much overlap in what affects what. These are figuratively countless numbers of on/off switches that regulate countless processes in your body including the immune system, DNA maintenance, hormone production, energy production and detoxification. I don't know if it's because of methylation but it has a significant effect on me. Outside the nucleus, folic acid can actually contribute to the methyl groups in your body. Eats a clean unprocessed diet, Mostly paleo. Methylation is complicated, but I'm going to get overly simplistic today to tell you what you need to know about undermethylation. Any suggestions appreciated. Meats, Fish, Shellfish, Organ meats grass-fed, hormone/anti-biotic free meats, fresh (not farmed) fish. Carrots Additionally it may be important to avoid folic acid as levels may be abnormally high throughout neurons. The .gov means its official. Ive read Nutrient Power by DR. Walsh and what he says about folic acid having a negative impact on mood and emotions for people who are undermethylated seems to hold true for me. Thanks, :-). Helps recycle folate so it's a usable methyl donor form. Undermethylation affects the bodys access to Methyl-B12. The fact is medical doctor or not no one has a clue how this stuff works. This study examined uptake and metabolism of caffeine in lettuce in a hydroponic system. Id say no, given most websites say under methylators have high homocysteine but this page says they have low homocysteine. Dr. Ben Lynch, the designer of Strategene, says that properly managing stress, sleep, diet, exercise, and environment, is sometimes all the treatment you need for your body to work efficiently. I gave up caffeine for four long, miserable years without it. Look at Dr. Tom OBryans website for info on that. While these generally are not severe, then can interfere with the accuracy of a persons perception of reality. MTHFR is an acronym for Methylenetetrahydrofolate Reductase. MTHFR is an enzyme and the MTHFR gene is necessary for the creation of the enzyme which regulates the methyl cycle. Orange Other supportive nutrients on a case-by-case basis: Using whole blood histamine levels to assess methylation status is not without controversy. I am very poor, on benefits and live in Manchester UK. Your email address will not be published. This site is dedicated to helping you understand and treat issues regarding imbalanced methylation and therefore your state of health. Undermethylation. This can lead to perfectionism, high accomplishment, and high achievement (overdrive). Also the lack of motivation a strong sense of inner direction leaves me unaffected by extrinsic status/labels, and addictive personality everything is intense for me, everything becomes an obsession because I ruminate unendingly, which has also made it hard for me to take practical steps (do sh#t) and manage time well. Rhubarb Depression, Anxiety and Insomnia: low levels of serotonin and dopamine will make one susceptible to depression, anxiety and insomnia. I have severe hair loss and long time history of depression. There are different genetic polymorphisms of the MTHFR gene as well as other factors that may dictate your experience. Noticing a theme in the foods listed above? If you are taking a medication and have a mutation of MTHFR that leads to overmethylation, below are some likely reactions. Undermethylation can occur when methyl molecules are insufficient. National Library of Medicine He would love to move on with his life. Caffeine has been frequently detected in agriculture produce; however, little attention is given to its metabolites in vegetables. If you get stuck go to This condition has too few methyl groups (a carbon group with three hydrogen atoms) which help regulate neurotransmitter activity. Asparagus The second of the four biochemical subtypes, is undermethylation. The following vitamins/ minerals work for me: -Niacin I take Wellbutrin XL and brintellix, working okay. edition (May 6, 2014). I am lucky in that it doesn't cause me to experience panic attacks.
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